Immunogen, Inc.

Brenda A Kellogg

Rajeeva Singh

Ravi V J Chari

Ravi Chari

Ravi VJ Chari

This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues.

Methods for preparing a purified maytansinoid conjugate in a solution

Methods for preparing antibody-drug conjugates

Conjugation methods

Methods for preparation of antibody-maytansinoid conjugates

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Medford, MA, United States of America

Brenda A Kellogg