Fmc Corporation

Theravance Biopharma R&d IP, LLC

E.i. Dupont De Nemours and Company

Breena Gloriana Fraga

Wenming Zhang

David Alan Clark

Robert Murray McKinnell

Erik Fenster

Tom M Lam

Anthony Francesco Palermo

Diana Jin Wang

Miroslav Rapta

Venkat R Thalladi

Marta Dabros

Jerry Nzerem

Mandy Loo

Luke Boralsky

The disclosure provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.

Fused pyrimidine pyridinone compounds as JAK inhibitors

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q is and A, R, m, X, X, X, X, Y, Yand Yare as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Heterocycle-substituted bicyclic azole pesticides

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein and A, R, m, X, X, X, X, Y, Yand Yare as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides crystalline forms, pharmaceutical compositions comprising such compounds, methods of using such compounds to treat gastrointestinal and other inflammatory diseases, and processes and intermediates useful for preparing such compounds.

Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors

Growing community of inventors

Madera, CA, United States of America

Breena Gloriana Fraga