Lek Pharmaceuticals D.d.

Lek, Tovarna Farmacevtskih in Kemicnih Izdelkov, D.d.

Lek, Tovarna Farmacevtskih

Lek, Tovarna, Farmacevtskih in Kemicnih . . .

Breda Bole-Vunduk

Rudolf Rucman

Igor Krisch

Bogomila Lavric

Magdalena Ocvirk

Janko Zmitek

Katarina Verhnjak

Uros Urleb

Darja Fercej-Temeljotov

Mateja Kovacic

Marko Zivin

Natasa Milivojevic

Anton Lavric

The present invention belongs to the field of pharmaceutical industry and relates to a new method for the treatment of psychostimulant addiction, in particular cocaine addiction, or pharmaceutically acceptable acid addition salts thereof, with a therapeutically effective amount of 9,10-didehydro-N-methyl-N-(2-propy-nyl)-6-methyl-8&#x3b2;-aminomethylergo-line in the form of free base or in the form of pharmaceutically acceptable addition salt, in particular the bimaleate salt, as well as pharmaceutical compositions containing said compound. In literature, the compound is also known under code LEK-8829. More particularly, present invention relates to a novel method of treatment for reduction of abstinence symptoms after cocaine withdrawal and for suppression the symptoms of craving for cocaine withdrawal and for suppression the symptoms of craving for cocaine reinforcement, and to the use of said active substance for the preparation of the pharmaceutical composition for the treatment of cocaine addiction. In addition to the treatment of cocaine addiction, the present invention also relates to the method for treatment of the addiction with amphetamine, methamphetamine, dextroamphetamine, 3,4-methylenedioxymethamphetamine and pemoline or acid addition salts thereof.

Treatment of psychostimulant addiction

Inclusion complexes of racemic ibuproxam and of optically active

A method of treating psychosis including administering an antipsychotically effective amount of an ergolinyl derivative of 2-propinylamine of the formula I ##STR1## wherein, R.sub.1, R.sub.2, and R.sub.3 independently represent a hydrogen atom or a straight-chain or branched-chain C.sub.1 -C.sub.6 alkyl group, X represents a hydrogen or a halogen atom, Z represents a carbonyl or methylene group, and C.sub.9 - - - -C.sub.10 represents a single or a double, diastereomeric forms, racemates and acid addition salts thereof.

Ergoline derivatives of 1-propinylamine, a process for the manufacture

There are disclosed novel ergoline derivatives of 2-propinylamine of the general formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently represent a hydrogen atom or a straight-chain or branched-chain C.sub.1 -C.sub.6 alkyl group,

Ergoline derivatives of 2-propinylamine, a process for the manufacture

Growing community of inventors

Ljubljana, Slovenia

Breda Bole-Vunduk