Fundacao Oswaldo Cruz

Braulia Costa Caetano

Ricardo Tostes Gazzinelli

Rafael Polidoro Alves Barbosa

Alexandre De Magalhaes Vieira Machado

Oscar Bruna-Romero

Flavio Fonseca Guimaraes

Erica Araujo Mendes

Oscar BRUÑA-Romero

ÉRica Araújo Mendes

Flávio Fonseca GUIMARÃES

The present invention concerns to recombinant influenza viruses and modified Vaccinia Ankara viruses (MVA), and to a process for construction of recombinant influenza viruses and modified vaccinia Ankara viruses (MVA) with genes that encode for theparasite SAGI (MVA) and SAG2 (MVA and influenza) proteins, by means of a homologous recombination technique between two transfer vectors (for construction of MVA virus) and reverse genetics (for construction of influenza virus). Additionally, the present invention describes a vaccine composition using recombinant influenza viruses and modified vaccinia Ankara viruses (MVA), or recombinant adenoviruses and modified vaccinia Ankara viruses (MVA), for immunization against infections caused by theparasite.

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Belo Horizonte, Brazil

Braulia Costa Caetano