Emory University

The Uab Research Foundation

Wisconsin Alumni Research Foundation

Children's Healthcare of Atlanta, Inc.

Brantley R Herrin

Max Dale Cooper

Matthew N Alder

Eric V Shusta

Christopher B Doering

H Trent Spencer

Rudolf Ehrhardt

Benjamin J Umlauf

Paul A Clark

John Kuo

Jason M Lajoie

The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the blood brain barrier, compositions, and methods of use.

Variable lymphocyte receptors that target the blood brain barrier and methods of use

The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the brain extracellular matrix, compositions, and methods of use. Methods of using the variable lymphocyte receptors for the detection and treatment of disease or injury, specifically, for example, cancers including glioblastoma are provided.

Variable lymphocyte receptors that target the brain extracellular matrix and methods of use

Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal, and multivalent forms, as well as methods of using the polypeptides, antibodies that bind the antigen specific polypeptides, and nucleic acids, vectors and expression systems that encode the polypeptides. Antigen specific polypeptides that selectively bind pathogens, like anthrax, and carbohydrates, like blood group determinants, are specifically disclosed.

Methods and compositions related to soluble monoclonal variable lymphocyte receptors of defined antigen specificity

This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and uses related thereto. In certain embodiments, the disclosure relates to recombinant polypeptide VLRs disclosed herein and variants thereof. In certain embodiments, this disclosure relates to treating or preventing a disease or condition comprising administering an effective amount of a recombinant polypeptide or variant disclosed herein to a subject in need thereof.

Recombinant vector and expression system comprising a nucleic acid encoding a variable lymphocyte receptor (VLR)

This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.

Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer

Modified recombinant variable lymphocyte receptors (VLR)

Growing community of inventors

Decatur, GA, United States of America

Brantley R Herrin