USA As Represented by Secretary of the Navy

Brandy J White

Baochuan Lin

Brian Melde

Frances S Ligler

James B Delehanty

Mazyar Zeinali

Martin H Moore

David A Stenger

Michael A Markowitz

Paul T Charles

Chris Rowe Taitt

Anthony P Malanoski

Zheng Wang

Gaurav J Vora

Jeffrey S Erickson

The application of melanin to fabric improves resistance to chemical pass-through, with possible application in protective garments, shelters, and filtration materials.

Melanin-based chemical protective materials

Systems and methods are provided for identification of a detection event relevant in applications focused on real-time or near real-time reporting in a continuous monitoring application. A controller collects data from a plurality of sensors and compares recent data to background data to determine whether an event has occurred. A system in accordance with an embodiment of the present disclosure is considered to have detected an event of interest when at least a specified minimum number of sensors report a detection event at the same time.

Analyzing reflectance based color changes in sensing applications

Mesoporous sorbents are effective for storing and transporting nucleic acids. In particular, two ethane-bridged silica sorbents with amine functionalities are particularly effective and capable of binding nucleic acids for storage.

Sorbents for the extraction and stabilization of nucleic acids

Sorbents for extraction and stabilization of nucleic acids

Mesoporous organosilica sorbents are effective to remove contaminants (such as glycerol or detergent) from biodiesel. Contacting biodiesel with various a mesoporous organosilica sorbents comprising phenyl and sulfonate moieties resulted in the contaminants being absorbed by the sorbent and thus removed from the biodiesel.

Sorbent design for improved glycerol adsorption

Described herein are modification of fabrics using a microwave initiation technique to produce a porous coating on the fibers providing adsorbent properties as well as the potential for further modification. In embodiments, the fabric incorporates a periodic mesoporous organosilica compound (PMO) optionally bound to a porphyrin or other functional group, and/or a catalyst or optical indicator.

Microwave initiation for deposition of porous organosilicate materials on fabrics

Porphyrin-modified antimicrobial peptides as described here may be used as indicators of the presence of microbial targets. Their application may be as (for example) (1) fluorescent indicators in a microarray format, (2) fluorescence or absorbance based indicators in traditional solution based applications, or (3) reflectance based indicators for use in reagent-less detection platforms.

Porphyrin&#x2014;modified antimicrobial peptides for application as indicators of microbial targets

A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.

Binding interaction of proanthocyanidins with bacteria and bacterial components

A composition having: a proanthocyanidin; and a macromolecule, an assembly of macromolecules, a semi-solid, or a solid surface to which the proanthocyanidin is immobilized.

Applications of the binding interaction of proanthocyanidins with bacteria and bacterial components

Provided photo-decontamination catalyst material comprising an optically active molecule embedded/incorporated/bridged in a periodic mesoporous organosilica (PMO). The optically active molecule is a typically a fluorophore or chromophore, more specifically, a porphyrin or phthalocyanine. The periodic mesoporous organosilica can be a template directed molecularly imprinted periodic mesoporous organosilica. The PMO material incorporating an optically active molecule is useful as a catalyst in photo-decontamination applications, as well as a detection element for stand-off point detection system.

Fluorphore embedded/incorporating/bridged periodic mesoporous organosilicas as recognition photo-decontamination catalysts

Periodic mesoporous organosilicas (PMO) which incorporate an optically active molecule into the material for use as an optical indicator of target binding. This material combines the stability, selectivity, and high density of binding sites characteristic of the PMO with the sensitivity and selectivity of the optically active molecule. The material undergoes a change when exposed to a sample containing a target molecule. The change can be observed by visual inspection or through the use of fluorescence spectra.

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Washington, DC, United States of America

Brandy J White