Illumina Corporation

Tearlab Research, Inc.

Brandon Westerberg

Philip Y Paik

Jay Taylor

Tsukasa Takahashi

James Michael Osmus

Jack Godfrey Wood

Bradley Kent Drews

Carlos Dominguez

Benjamin D Sullivan

Erik Allegoren

Paul Crivelli

Cyril Delattre

Darren Segale

Matthew William Hage

Matthew Daniel Solomon

Wesley A Cox-Muranami

Jennifer Olivia Foley

Minsoung Rhee

Erol Craig Harvey

Peter Van Ruijven

Matthew Springer

Steve Zmina

David Hertzog

Alex Moroz-smietana

Jeffrey Liu

Xiaoxiao Ma

Derek Lee

Joanna Slowinska

Michael Wilkinson

Peter Munster

Jason Hayes

Sebastiaan Garst

Christian Potzner

Melissa Lee

An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

Flow cell with flexible connection

Flow cell device

Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest

Growing community of inventors

San Diego, CA, United States of America

Brandon Westerberg