Fluidigm Corporation

Bayer Healthcare LLC

Brandon Ripley

Gang Sun

Jake Kimball

Dominique Toppani

Myo Thu Maung

Jared E Neff

Scott Griffith

Joseph E Bisegna

Paul J Miller

James H Shigeno

Leon J Tate

Edward Ilgenfritz

A thermal cycler for a microfluidic device includes a controller operable to provide a series of electrical signals, a heat sink, and a heating element in thermal communication with the heat sink and operable to receive the series of electrical signals from the controller. The thermal cycler also includes a thermal chuck in thermal communication with the heating element. The thermal chuck comprises a heating surface operable to make thermal contact with the microfluidic device. The heating surface is characterized by a temperature ramp rate between 2.5 degrees Celsius per second and 5.5 degrees Celsius per second and a temperature difference between a first portion of the heating surface supporting a first portion of the microfluidic device and a second portion of the heating surface supporting a second portion of the microfluidic device is less than 0.25&#xb0; C.

System for thermal cycling of microfluidic samples

A fluid path set for a fluid delivery system includes a tube coil that is designed to optimally position one or more volumes of a pharmaceutical within an ionization chamber to measure and prepare a pharmaceutical dose for administration to a patient. Methods for priming at least a portion of the fluid path set include placing a tubing section of the fluid path set in fluid connection with a source of a radiopharmaceutical, and placing the tube coil within a dose calibrator of the fluid delivery system. A volume of the radiopharmaceutical may be pumped through the tube coil, the tubing section, and an additional tubing section, and the dose calibrator may be monitored to determine if a measured activity level is substantially equal to or above a predetermined activity level, and if so, it may be concluded that the tubing section of the fluid path set has been primed.

Radiopharmaceutical administration methods, fluid delivery systems and components thereof

Method for thermal cycling of microfluidic samples

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San Francisco, CA, United States of America

Brandon Ripley