St. Jude Children's Research Hospital

Aviara Pharmaceuticals, Inc.

Pfizer Corporation

Brandon M Young

Nagakumar Bharatham

Ronald J Biediger

Robert V Market

Jaeki Min

R Kiplin Guy

Richard Kriwacki

Michael M Savage

Michael Dyer

Antonio Ferreira

Vincent A Boyd

Kristin Finch

Donald Bashford

Michele A Benish

Lie Min

Yiqun Zhang

R Kip Guy

Jeanine E Price

Anang Shelat

P Jake Slavish

Grace Roy-Appa

William Robert Shadrick

Jie Chen

Keith Allen Monk

Brian Dupre

Pedro Lory

Reginald L Tennyson

Grace Royappa

Lindsay Bonner Hardy

Thomas P Thrash

Eric C Anderson

Anthony Ferreira

In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Tetrahydroquinoline-based bromodomain inhibitors

Provided herein are compounds and pharmaceutical compositions of formula I where R, R, R, R, Rand Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Propionic acid derivatives and methods of use thereof

The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Aryl-substituted imidazoles

Provided herein are methods for antagonizing the action of an &#x3b1;4-integrin to treat various pathophysiological conditions utilizing pharmaceutical compositions of compounds or pharmaceutically acceptable salts or stereoisomer(s) thereof of formula I where R, R, R, R, R, X and Rare as described herein.

Provided herein are compounds and pharmaceutical compositions of formula I where R, R, R, R, R, X and Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomer(s) of these compounds. In addition methods are provided for antagonizing the action of an &#x3b1;4-integrin to treat various pathophysiological conditions.

Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modulation of CCR9 receptor activity.

Modulators of CCR9 receptor and methods of use thereof

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Germantown, TN, United States of America

Brandon M Young