Columbia University

Brandon Guenthart

Gordana Vunjak-Novakovic

John O'Neill

Matthew D Bacchetta

Scott Chicotka

Kenmond Fung

Jinho Kim

Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs

Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak.

Cell-seeded porous lung hydrogel sealant

Growing community of inventors

New York, NY, United States of America

Brandon Guenthart