Intrexon Corporation

Precigen, Inc.

Brandon Cuthbertson

Sunil D Chada

William E Fogler

Charles C Reed

Jeremiah F Roeth

Fayaz Khazi

Sunil Chada

This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immuunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.

Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof

This invention relates to the field of therapeutics. Disclosed are methods of conditionally expressing erythropoietin under the control of an ecdysone receptor-based gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. The methods of the invention cause an in vivo increase in the expression of erythropoietin and an increase in the hematocrit or volume percentage of red blood cells in blood after administration of the ligand.

Vectors conditionally expressing protein

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Newland, CT, United States of America

Brandon Cuthbertson