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Brajendra Kumar Tripathi

Arvind Kumar Srivastava

Ram Pratap

Priti Tiwari

Ram Raghubir

Chandeshwar Nath

Anju Puri

Mavurapu Satyanarayana

Ramesh Chander

The present invention provides appropriately substituted chalcones, such as, for example, represented by the structural formula as shown herein below Wherein R1, R2 and R3 are selected from the group consisting of H, OH, O-alkyl, O-phenyl and O-substituted phenyl; B represents Ar&#x2014;Z&#x2014;O or RO; where Z is an alkane having up to 5 carbon atoms; R is substituted propanol amino, wherein substituted amino groups are selected from the group consisting of t-butyl, n-butyl, i-butyl, i-propyl, 4-phenyl piperazine-1-yl, 4-(2-methoxyphenyl)-piperazin-1-yl and 3,4-dimethoxy phenethyl; and Ar is thiazolidine-dione methylene phenoxy. The compounds prepared have been demonstrated to exhibit significant antidiabetic effect in various animal models indicating potential for further exploitation.

Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents

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Lucknow-226001, India

Brajendra Kumar Tripathi