Nucleic Acid Research Institute

Brahma S Sharma

Roland K Robins

Ganapathi R Revankar

##STR1## 6-Amino-1-(2-deoxy-.alpha.D-erythro-pentofuranosyl)imidazo [4,5-C]pyridin-4-one (also know as .alpha.-2'-deoxy-3-deazaguanosine) is non mitogenic to human peripheral blood lymphocytes; however, it displays a potent immunoenhancing activity on human T cells. This compound causes a marked increase in both phytohemagglutinin and Concanavalin A induced proliferation of T cells. When added during allogeneic mixed lymphocyte response, it also potentiates the proliferation of alloreative T cells. The compound shows no potentiating effect on B lymphocytes activated either with Staphylococcus aureus cowan or Pokeweed mitogen, suggesting that it is mainly a T cell function immunopotentiator. The compound overcomes induced immunosuppression and is able to restore depressed proliferative responses of T cells. Further it potentiates the generation of antigen-specific primary cytotoxic T lymphocytes.

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Irvine, CA, United States of America

Brahma S Sharma