Nanyang Technological University

Brahim Heddi

Vee Vee Cheong

Anh Tuan Phan

Kah Wai Lim

Christopher Brian Henry Jacques Lech

Herry Martadinata

The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.

G-quadruplex-containing antisense oligonucleotides

A peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a derivative thereof is provided. Also provided are conjugates of such a peptide, the use of the peptide or the conjugates as a medicament, and methods for the detection of parallel-stranded G-quadruplexes.

Growing community of inventors

Singapore, Singapore

Brahim Heddi