National Institutes of Health, a Component of the US Dept. of Health & Human Services

Bradley T Scroggins

Leonard M Neckers

John A Beutler

W Marston Linehan

Jane B Neckers

Min-Jung Lee

Sunmin Lee

Carole Ac Sourbier

Carole Sourbier

Disclosed is a method of activating protein kinase C theta (PKC&#x3b8;) in an HIV or HTLV infected animal comprising administering to the animal an effective amount of a compound of formula (I): Formula (I), or an epimer thereof; wherein Ar and R-Rare described herein. Examples of diseases or conditions associated with PKC&#x3b8; include HIV1 infection, AIDS, HTLV infection, and adult T cell leukemia/lymphoma. 

Methods of treating patients infected with HIV and HTLV

Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R-Rare described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality. 

Methods of treating or preventing insulin resistance and associated diseases and conditions

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Rockville, MD, United States of America

Bradley T Scroggins