Biomed Valley Discoveries, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America As Represented by the Department of Health

Bradley St Croix

Dimiter Stanchev Dimitrov

Zhongyu Zhu

Saurabh Saha

Rimas J Orentas

Crystal L Mackall

Dean Welsch

Xiaoyan Michelle Zhang

Steven Seaman

Gary DeCrescenzo

Gary A Decrescenzo

Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.

Anti-CD276 antibodies (B7H3)

Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

Anti-CD276 polypeptides, proteins, and chimeric antigen receptors

Growing community of inventors

Frederick, MD, United States of America

Bradley St Croix