University of California

Other

Bradley S Moore

William H Gerwick

Frederick A Valeriote

Gilbert L Bundy

Andrew T Fenley

Jonathan R Chekan

Michael Kenneth Gilson

Shaun M K McKinnie

Tara Byrum

Alban R Pereira-Badilla

Andrew Kale

Hosana Debonsi

Provided herein are compounds of Formulas (la), (lb), (II) to (VIII), and salts thereof, and methods of making the same. Also provided herein are recombinant proteins useful in the production of compounds disclosed herein, polynucleotides encoding the same, and cells comprising the same.

Scalable biosynthesis of the seaweed neurochemical kainic acid

In particular, in alternative embodiments, the invention provides pharmaceutical compounds and formulations comprising a family of epoxyketone compounds, which include racemic mixtures or racemates, isomers, stereoisomers, diastereoisomers, derivatives and analogs, and methods for making and using them. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered to an individual in need thereof in an amount sufficient to treat, prevent, reverse and/or ameliorate an infection, disease or condition that can be ameliorated, treated, prevented or reversed by partially or completely inhibiting a chymotrypsin-like protease or a proteasome activity, including e.g., a retroviral infection such as human immunodeficiency virus-1 (HIV-1) infection, an immune disorder, a neurodegenerative disease or condition, or a cancer such as a myeloma or multiple myeloma, an adenocarcinoma such as a lung adenocarcinoma, a pancreatic cancer, a B-cell related cancer, and lymphomas such as non-Hodgkin's lymphoma.

Compositions and methods for inhibiting proteases

A method for removing non-stick coatings from cookware or bakeware products is disclosed. The method includes the step of determining the angles of the primary surfaces of a pan having a coating to be removed. The method further includes the step of configuring a high-speed, multiport, rotating cleaning head to provide at least one water jet associated with each primary surface. The method further includes the step of employing the cleaning head to deliver an ultra-high pressure water jet directed at the pan while tracking the cleaning head along a plane substantially parallel to the upper surface of the pan. Using the method of the present invention, a coating may be removed from a pan in a single pass.

Method for removal of cured films from cookware and bakeware products

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La Jolla, CA, United States of America

Bradley S Moore