Johns Hopkins University

Bradley P Barnett

Jef D Boeke

Philip A Cole

Philippe Gailloud

Albert S Jun

Yousang Hwang

Lacrimal canalicular delivery systems (LCDS) and their methods of use for the delivery of implants at a specific location into the canaliculus of a subject generally include a lumen, a guide wire, and an implant. The guide wire and implant are within the lumen. When pressure is applied to the guide wire, the guide wire pushes the implant out of the lumen into a specific location into the canaliculus of a subject.

Lacrimal canalicular delivery system and methods of use

The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention also provides kits and instructions for use.

Alginate and alginate lyase compositions and methods of use

The invention provides inhibitors of ghrelin O-acyltransferase, and methods of making and using them. In some embodiments, the invention provides bisubstrate analog inhibitors of ghrelin O-acyltransferase, which can be effective in treating, for example, obesity and diabetes mellitus.

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Baltimore, MD, United States of America

Bradley P Barnett