Roche Palo Alto LLC

Bradley E Loc

Zachary Kevin Sweeney

Yan Lou

Timothy D Owens

Michael Soth

Rama K Kondru

Nolan James Dewdney

Joel McIntosh

Joshua Kennedy-Smith

Joshua Paul Gergely Taygerly

This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-III: wherein, variables R, X, Y, Y, Y, Y, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.

Inhibitors of Bruton's tyrosine kinase

Growing community of inventors

Santa Cruz, CA, United States of America

Bradley E Loc