Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Bradley David Olsen

Matthew J Glassman

Reginald Keith Avery

Gareth H McKinley

Hadley Sikes Johnson

Alireza Khademhosseini

Eric Alexander Miller

Desiree L Plata

Justin Paloni

Akhilesh K Gaharwar

Wontae Joo

K'yal Rasean Bannister

Omar Tantawi

Sarah Av-Ron

Brian M Seifried

Yun Jung Yang

Jacqueline Chan

Sieun Kim Barnes

Allie Obermeyer

Carla S Thomas

Minkyu Kim

Wui Yarn Chan

Kristala L Jones Prather

Skin hydration is necessary to maintain the epidermal barrier, minimize adverse environmental influences, and reduce cell stress. Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically and cosmetically acceptable salts thereof, and compositions, methods, and uses that may be used for skin hydration. Also reported herein is a scalable method for synthesizing compounds of Formula (I). The compounds provided herein are responsible for improved skin penetration and/or retention and are therefore useful for the treatment and/or prevention of various diseases, disorders, or conditions to protect human skin.

Hyaluronic acid derivatives

Disclosed is a copolymer comprising a hydroxyacid, wherein the copolymer is biodegradable with a decomposition temperature is substantially higher than its melting temperature. Also disclosed is a method of synthesis of a poly(pivalolactone-co-caprolactone) copolymer.

Biodegradable sustainable polyesters

The present disclosure relates to protein-polymer conjugates comprising an engineered binding oligomer protein and a polymer for detection of a ligand of interest, methods, compositions and kits thereof.

Oligomerized protein-polymer conjugates

Disclosed are copolymers comprising a modified protein first monomer, a surfactant, and a second monomer. Methods of making copolymers comprising a modified protein first monomer, a surfactant, and a second monomer are described. Also disclosed are articles comprising the copolymers. Disclosed are blends comprising a protein, a surfactant, and a second monomer. Methods of making blends comprising a protein, a surfactant, and a second monomer are described. Also disclosed are articles comprising the blends.

Protein-surfactant-monomer/polymer blends and copolymers for protein-based plastics

Elastin-like polypeptides (ELPs) form hydrogels upon heating. The polypeptides can comprise the generic sequence (XPAVG)(SEQ ID NO: 4), wherein independently for each occurrence X can be any one of a number of different natural or unnatural amino acids, and n is chosen to determine the size of the protein. Hydrogels comprising the polypeptides have mechanical properties, including elastic modulus and fracture toughness, required for load-bearing applications.

Thermoreversible hydrogels from the arrested phase separation of elastin-like polypeptides

Disclosed are synthetic polypeptides modeled after NspI nucleoporin which are useful for forming hydrogels characterized by selective permeability. The polypeptides and hydrogels formed from them include phenylalanine-glycine (FG) repeats, which are believed to participate in the selectivity of the nuclear pore complex. Also disclosed are filtering devices, drug delivery devices, and methods of separating or selectively filtering macromolecules using the hydrogels.

Artificially engineered protein hydrogels to mimic nucleoporin selective gating

Provided herein are hemostatic compositions useful for treating wounds in a patient in need thereof. An exemplary hemostatic comprises gelatin or a derivative thereof and silicate nanoparticles. Methods of use, kits comprising the compositions, and a process of making the compositions are also provided.

Nanocomposite hydrogels

Disclosed are protein brushes that mimic mucin in physical and functional characteristics. The protein brushes have a variable number of tandem repeats similar to natural mucin and are modified at a number of their tyrosine residues to introduce brush substituents that mimic the hydrogel nature of mucin.

High molecular weight, post-translationally modified protein brushes

Monomers and polymers, and a method of making polymers that retain the ability of the polymer to form reversible and irreversible bonds are provided. Gels comprising the polymers have the ability to coordinate metal ions and bind biopolymers.

Catechol-rich polymers from N-substituted maleimides

The present disclosure provides protein-containing compositions, methods and uses thereof. A conjugate comprises a globular protein conjugated with a polymer that preserves the folded and functional structure of a protein. In some embodiments, a fusion protein comprises a globular protein conjugated with an elastin-mimic polymer (EMP). Also disclosed is an assembled solid-state or gel-state nanostructure comprising a plurality of conjugates, wherein each comprises a globular protein conjugated with a polymer that preserving the folded and functional structure of a protein. In certain embodiments, provided compositions and methods further comprise an additive.

Protein-based conjugates and self-assembled nanostructures

Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating peptide or protein, and flexible linkers between the two. Hydrogels comprising the conjugates have the mechanical properties, including elastic modulus and fracture toughness, required for load-bearing applications, while maintaining desirable shear-thinning properties, for example, for injectability.

Growing community of inventors

Arlington, MA, United States of America

Bradley David Olsen