Medtronic Minimed, Inc.

Percusense, Inc.

Flotherm, Inc.

Raghavendhar, Gautham

Wolfe, Katherine T.

Liang, Bradley Chi

Shah, Rajiv

Little, Megan E.

Bradley Chi Liang

Rajiv Shah

Raghavendhar Gautham

Xiaolong Li

Keith Nogueira

Ning Yang

Katherine T Wolfe

Brian T Kannard

Kenneth W Cooper

Rebecca K Gottlieb

Mike C Liu

Andy Y Tsai

Taly G Engel

Jaeho Kim

Shaun M Pendo

Daniel E Pesantez

Anirban Roy

Barry Keenan

Ying Luo

Robert C Mucic

Andrea Varsavsky

Yuxiang Zhong

Wayne A Morgan

Jenn-Hann Larry Wang

Pratik J Agrawal

Michael E Miller

Benyamin Grosman

Randal C Schulhauser

Scott Michael Janis

Mohsen Askarinya

Larry Earl Tyler

Charles R Gordon

Jeffrey Nishida

Yiwen Li

Megan E Little

Ellen K Messer

Steven C Jacks

Peter Luke Santa Maria

Catherine M Szyman

Paris Chen

Manjunath Sirigiri

Carlos A Callirgos

Genival D De Barros

Joseph Paul Brinson

Kris R Holtzclaw

Fei Yu

Anuj M Patel

Abhinav Ramani

Colton Sanford

Isamu Taguchi

Bahar Sutorius

Zachary Decke

Ellen Bowman

Katherine Wolfe

Gautham Raghavendhar

Larry E Tyler

A heating system comprises a wearable sleeve, a first heating pad associated with a first portion of the wearable sleeve, a second heating pad associated with a second portion of the wearable sleeve, one or more temperature sensors associated with the wearable sleeve, and control circuitry communicatively coupled to the first heating pad, the second heating pad, and the one or more temperature sensors. The control circuitry is configured to receive one or more temperature signals from the one or more temperature sensors, determine a temperature associated with a patient based on the one or more temperature signals, determine that the temperature is less than a target temperature value, and at least partly in response to said determining that the temperature is less than the target temperature value, activate at least one of the first heating pad or the second heating pad.

Sleeve-based body temperature regulation

In one embodiment, a sensor is disclosed that includes a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The sensor includes a first electrode trace within the first conductive substrate with a plurality of first working electrode openings. The sensor also includes a second electrode trace within the first conductive substrate with a plurality of second working electrode openings. Additionally a first transport material is included that covers the plurality of first working electrode openings and a second transport material that covers the plurality of second working electrode openings. A third transport material covers, and forms a barrier between the first and the second transport material. The sensor additionally includes a counter-reference electrode that is formed on the second conductive substrate.

Analyte sensor

A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Sensor systems, devices, and methods for continuous glucose monitoring

Systems for maintaining normothermia in a patient via compression and warming are disclosed and include a first warming element configured to apply warming to the popliteal fossa, a second warming element configured to apply warming to the sole of the foot, and a compression element configured to apply compression to the calf.

Patient temperature and blood flow management

An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

A biosensor assembly that measures multiple physical parameters is disclosed. The biosensor assembly includes a first implantable probe and a first skin contacting electrode. Wherein a first physiological parameter is measured between the first implantable probe and the first skin contactable electrode.

System and method for disease risk assessment and treatment

A working electrode measuring the presence of an analyte is described as one embodiment. The working electrode includes a working conductor with a reactive surface that is operated at a first potential. The working electrode further includes a first transport material with properties that enable analyte flux to the reactive surface. Additionally, the working electrode has a second transport material with properties that enable reactant flux to the reactive surface, wherein the analyte flux and the reactant flux are in dissimilar directions.

A system to automatically detect at least one physiological state is disclosed. The system includes a single probe for insertion within a subject that has an analyte sensor array for continuous monitoring of at least glucose and a second analyte. The system further includes an electronics module that includes a power supply, a processor, memory and a bi-directional communications module. When the electronics module is coupled with the analyte sensor array the power supply delivers power to the analyte sensor array and the processor. The processor analyzing glucose and the second analyte data to detect a first physiological state from a plurality of physiological states.

Multi-analyte continuous glucose monitoring

The invention disclosed herein includes sensors having three dimensional configurations that allow expansive '360&#xb0;' sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Foldover sensors and methods for making and using them

An apparatus for early detection of sepsis in a host is disclosed. The apparatus includes a first sensor to directly measure a glucose level, a second sensor to directly measure a lactate level and a third sensor to directly measure a tissue oxygen level. The first sensor, the second sensor, and the third sensor all being inserted at a single point of entry in a subcutaneous space of the host such that a predetermined correlation between the glucose level, lactate level, and tissue oxygen level signals conditions related to sepsis.

Growing community of inventors

Bloomfield Hills, MI, United States of America

Bradley Chi Liang