Wyeth

Bradley Arnold Haltli

Edmund Graziani

Kevin Pong

John Hucul

Min He

Melissa M Wagenaar

Xidong Feng

Mia Summers

Kerry Kulowski

A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novelspecies and methods of modifiedspecies. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.

Biosynthetic gene cluster for the production of a complex polyketide

The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of streptomycete that is responsible for elaiophylin biosynthesis and that contains at least one gene or a part of a gene that codes for a polypeptide that is involved directly or indirectly in the biosynthesis of elaiophylin and to methods of preparing said DNA fragment. The present invention relates furthermore to recombinant DNA molecules containing one of the DNA fragments according to the invention and to the plasmids and vectors derived therefrom. Also included are host organisms transformed with the said plasmid or vector DNA.

Elaiophylin biosynthetic gene cluster

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Monsey, NY, United States of America

Bradley Arnold Haltli