Bioptigen, Inc.

Duke University

Biotigen, Inc.

Bradley A Bower

Eric L Buckland

Robert H Hart

Joseph A Izatt

Pete Huening

Christopher E Saxer

Igor Touzov

Bennett R Groshong

Cynthia A Toth

Ryan Christopher Gessner

Kenneth Wayne Chapman

Peter Huening

Marcin Stopa

Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.

Systems and methods for quantitative doppler optical coherence tomography

Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.

Methods for comprehensive Fourier domain optical coherence tomography (FDOCT)

Systems for imaging a sample are provided. The system includes an OCT imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The illumination path includes a multi-wavelength source of optical radiation.

Compact multimodality optical coherence tomography imaging systems having a ring of optical fibers in image capture path

Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first unique code falls into at least one of the classes of objects associated with the reference codes based on a result of the comparison; and formulating a diagnostic decision based on the whether the first unique code associated with the subject falls into at least one of the classes associated with the reference code. Related systems and computer program products are also provided herein.

Methods, systems and computer program products for diagnosing conditions using unique codes generated from a multidimensional image of a sample

Wavenumber linear spectrometers are provided including an input configured to receive electromagnetic radiation from an external source; collimating optics configured to collimate the received electromagnetic radiation; a dispersive assembly including first and second diffractive gratings, wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array such that the variation in frequency spacing along the linear detection array is no greater than about 10%.

Linearized variable-dispersion spectrometers and related assemblies

Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane. Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.

Systems for comprehensive fourier domain optical coherence tomography (FDOCT) and related methods

Methods are provided including receiving a plurality of images from at least one image acquisition system; selecting at least a portion of a set of images for analysis using at least one attribute of image metadata; selecting at least one method for deriving quantitative information from the at least a portion of the set of images; processing the selected at least a portion of the set of images with the selected at least one method for deriving quantitative information; associating the derived quantitative information with the at least a portion of the set of images via a data structure; selecting at least one method for aggregating at least a portion of a set of derived quantitative information into a reduced set of results; and generating at least one report to represent the reduced set of results for one of an individual image and the set of images as a pool.

Database and imaging processing system and methods for analyzing images acquired using an image acquisition system

Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

Systems for extended depth frequency domain optical coherence tomography (FDOCT) and related methods

Compact multimodality optical coherence tomography imaging systems

Methods of collapsing volume data to a lower dimensional representation of the volume data are provided. The methods include collapsing volume data to a lower dimensional representation of the volume data using histogram projection. Related systems and computer program products are also provided.

Methods, systems and computer program products for collapsing volume data to lower dimensional representations thereof using histogram projection

Optical coherence tomography (OCT) imaging systems for imaging uniquely identifiable structure are provided including a source having an associated source arm path and having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. Processing methods to convert the depth-dependent image data to a uniquely identifiable code are provided. Related methods and computer program products are also provided.

Growing community of inventors

Hillsborough, NC, United States of America

Bradley A Bower