Abbvie Inc.

Abbott Laboratories Corporation

Bradford L McRae

Chung-Ming Hsieh

Yuliya Kutskova

John Memmott

Jennifer Maria Perez

Mary Leddy

Anwar Murtaza

Anca Clabbers

Margaret Hugunin

Suju Zhong

Edit Tarcsa

Craig Wallace

Shaughn H Bryant

Lorenzo Benatuil

Steven Grant

Ian M Tomlinson

Michael Roguska

Mihriban Tuna

Gillian A Kingsbury

John E Harlan

Rui Wang

Russell A Judge

Carrie Enever

The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.

Anti-CD40 antibodies

Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

IL-17 binding proteins

Proteins that bind IL-17 and/or IL-17F are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1&#x3b1; and human IL-1&#x3b2;. The dual specific antibodies of the invention also neutralize both human IL-1&#x3b1; and human IL-1&#x3b2;. The invention also provides domain antibodies (dAbs) specific for human IL-1&#x3b1; and human IL-1&#x3b2;.

Dual-specific IL-1&#x3b1;/IL-1&#x3b2; antibodies

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Northborough, MA, United States of America

Bradford L McRae