Coda Therapeutics, Inc.

Ocunexus Therapeutics, Inc.

Auckland Uniservices Limited

Amylin Pharmaceuticals, Inc.

Coda Technologies, Inc.

Ocunexus Theraprutics, Inc.

Coda Therapeuctics, Inc.

Bradford James Duft

Colin Richard Green

David Laurence Becker

Anthony Phillips

Tracey Sunderland

Scott Bannan

David Eisenbud

Grove Matsuoka

David Pool

Yeri Kim

Orville G Kolterman

David Lawrence Becker

Odunayo Omolola Boluwarin Mugisho

The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Channel modulators

The inventions relate to the use of hemichannel blockers to modulate cytokine levels in a subject, including the angiogenic cytokine, VEGF, and their production, secretion and/or release, and to the use of hemichannel blockers to reduce or level cytokine activity, including in conditions characterized in whole or in part by angiogenesis and/or vessel leak.

Cytokine modulation

Methods and compositions comprising combinations of one or more anti-connexin agents and one or more other agents useful for the promotion and/or improvement of wound healing and/or tissue repair.

Methods and compositions for wound healing

Medical devices comprising an anti-connexin agent suitable for introduction into a subject.

Medical devices

This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Wound healing compositions and treatments

Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.

Treatment of fibrotic conditions

Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.

Impaired wound healing compositions and treatments

Impaired wound healing compositions and methods

Growing community of inventors

Rancho Santa Fe, CA, United States of America

Bradford James Duft