Other

Depuy Synthes Products, Inc.

Mayo Foundation for Medical Education and Research

Medos International Sarl

Depuy Spine, Inc.

Depuy Acromed, Inc.

Bradford Currier

Carl Lauryssen

Michael F O'Brien

Gerald M Towns

John Riley Hawkins

Christopher L Ramsay

Mark T Hall

Kevin Lee

Joseph Peterson

Albert A Montello

Michael J Yaszemski

Heiko Koller

Kai-Nan An

Christopher Ames

Chunfeng Zhao

Lichun Lu

Masashi Neo

Todd Albert

Fredrick M Schultz

Benjamin Johnston

Esmaiel Jabbari

Claudius Thome

Thomas V Doherty

Martin A Reynolds

Shanfeng Wang

David M Selvitelli

Xun Zhu

Claudius Thorne

Haynes Louis Harkey, Iii

Patricia Neale

Diederik H R Kempen

Gerard M Towns

Louis Harkey

Bone anchor assemblies are disclosed herein that can provide for improved fixation as compared with traditional bone anchor assemblies. An exemplary assembly can include a bracket or wing that extends down from the receiver member. The distal portion of the wing can define a bone anchor opening through which one or more auxiliary bone anchors can be disposed to augment the fixation of the assembly's primary bone anchor. A distal surface of the distal portion of the wing can be obliquely angled relative to a proximal-distal axis of the spanning portion to face one of a caudal direction or a cephalad direction. A distal surface of the distal portion of the wing can be obliquely angled relative to the proximal-distal axis of the spanning portion to face one of a medial direction or a lateral direction. Surgical methods using the bone anchor assemblies described herein are also disclosed.

Multipoint fixation implants and related methods

A method of providing spinal stabilization is provided herein. More specifically, the method includes positioning a plurality of fixation assemblies within a plurality of vertebrae in a trans-lamina orientation wherein each fixation assembly includes a proximal portion configured to securely receive a stabilization element (e.g., a stabilization rod). The proximal portions of the various fixation assemblies can be aligned so as to secure at least one stabilization element in a desired position (e.g., along and above a midline of the patient's spine, adjacent and parallel to the midline). A system for providing spinal stabilization is also provided which utilizes trans-lamina delivery and positioning of fixation assemblies within target vertebrae thereby providing stronger fixation and a significant reduction in associated tissue damage.

Method and system for trans-lamina spinal fixation

The invention provides for a spinal fixation support device to be used in conjunction with spinal fixation instrumentation. The invention further provides for methods of using the spinal fixation support device. In addition, the invention provides for a spinal fixation system that includes a spinal fixation support device of the invention and can further include spinal fixation instrumentation.

Spinal fixation support device and methods of using

Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).

Block copolymers of polycarpolactone and poly (propylene funarate)

A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.

Hydroxyapatite grafted fumarate based macromers for biodegradable composites

A spinal fixation system and methods are provided that includes a plurality of pillars each positioned through a compromised vertebra and into the lower or upper endplates of the neighboring healthy vertebrae.

Microspheres for controlled release of a bioactive agent are disclosed, and in particular, blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery. The microsphere includes poly(propylene fumarate), a polymeric material other than poly(propylene fumarate) (e.g., poly(lactic-co-glycolic acid)), and a bioactive agent. The bioactive agent is selected depending on the physiological effect desired. For example, in bone regeneration applications, the bioactive agent may be selected from osteoinductive agents, peptides, growth hormones, osteoconductive agents, cytokines and mixtures thereof. The bioactive agent is dispersed in the microsphere, the microsphere has a diameter in the range of 1 to 300 micrometers, the poly(propylene fumarate) and poly(lactic-co-glycolic acid) are distributed in the microsphere, and the microsphere releases the bioactive agent in a sustained manner after an initial burst release. The microspheres may be covalently attached to a poly(propylene fumarate) scaffold for tissue regeneration applications in which the bioactive agent is released from the scaffold.

Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery

An apparatus for an expandable screw including an outer screw, a inner screw, and an end nut. An assembly and method for driving and expanding an expandable screw apparatus into a surface or structure. The assembly and method dynamically expand the expandable screw by driving and expanding the expandable screw simultaneously.

Expandable screw apparatus and method thereof

An orthopaedic method and anchor assemblies for anchoring a linkage such as a rod or cable used for fixation or reduction. One assembly includes an anchor plate and a slotted anchor bolt that captures the plate in a one-piece assembly for convenient installation. The base of the anchor bolt lies below the plate, and a cap or nut tightens down to secure a linking member, e.g., a rod or cable, in the slot, simultaneously clamping the bolt to fix both its position and its orientation on the plate. One occipital plate has lateral arms that hold the anchor bolts, and a Y-shaped embodiment is mounted in an inverted orientation to position the anchor bolts well down in soft tissue for more effective wound closure. A cable connector is used together with an anchor plate, vertebra anchor screws and fixation rods to secure ends of a cable at the level of one or more vertebrae, providing a versatile and highly stable system for alignment, fixation and fusing of the cervical and thoracic spine. The cable connectors have an open-sided channel that fits onto and securely clamps to an already-positioned fixation rod, with an eyelet or other structure providing a rigid and fixed securing point for a cable that is threaded about the vertebrae under tension. Methods of fixation are described.

Orthopaedic rod/plate locking mechanisms and surgical methods

Growing community of inventors

Rochester, MN, United States of America

Bradford Currier