Alpheus Medical, Inc.

Gravitas Medical, Inc.

Magnetic Mechanisms L.l.c

University of Minnesota

Braden Eliason

Vijay Agarwal

Jeremy Ling

Joseph Funk

Jeffery M Eliason

Gregg Miller

Mitchell Porch

Benjamin J Larsen

Arthur Spivy

John Ballard

Daniel Rogers Burnett

Daniel R Burnett

Jafar Golzarian

Saheel Sutaria

Elliott Bennett-Guerrero

Rebecca E Wereley

David A Melander

Enio T Perez Filho

Aaron Koenigsberg

Reza Talaie

Eliott Bennett-Guerrero

Methods and apparatus for guiding medical care based on sensor data from the gastrointestinal tract are described utilizing an apparatus which can be used with enteral feeding. Generally, the apparatus includes an elongated body having a length configured for insertion into a stomach and at least one pair of electrodes located along the length of the elongated body and positionable for placement within the stomach. A controller in electrical communication with the at least one pair of electrodes is included and the control may also be configured to measure a conductivity or impedance between the pair of electrodes and to determine a gastric residual volume of the stomach based on the measured conductivity or impedance.

Methods and apparatus for guiding medical care based on sensor data from the gastrointestinal tract

Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

Ultrasound arrays for enhanced sonodynamic therapy for treating cancer

Techniques are disclosed for extended-reality (XR) visualization of a flexible medical tool. In one example, sensor(s), disposed near a distal portion of a flexible shaft of a medical tool configured for insertion into a patient, sense values indicative of a pose of the medical tool with respect to an EM field. A computing device adjusts, based on the sensed values, a relative alignment between the medical tool, an internal anatomy of the patient, and an exterior of the body of the patient. The computing device generates, based on the computed relative alignment between the medical tool, the internal anatomy, and the exterior of the body, XR content comprising a visual representation of the medical tool within the patients internal anatomy, and outputs the XR content for display to a user so as to simulate a current pose of the medical tool relative to the body of the patient.

Extended-reality visualization of endovascular navigation

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as drugs, may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate as compounds such as a protoporphyrin compound in tumor cells. After such accumulation, such compounds are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

Methods of treating cancer with drugs

Incoherent field sonodynamic therapy for treating cancer

Disclosed are methods of producing randomized ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Methods of producing randomized ultrasound waves for sonodynamic therapy

Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Methods of using planar or defocused acoustic waves for non-invasive sonodynamic therapy

A device for attachment to a surface of a ferromagnetic object and for holding an item near the surface, including: a base with a frame and grip portion, the grip portion coupled to the frame at the rear side and having an outer surface for gripping the surface; a magnet-retaining portion pivotally connected to an end of the frame; a magnetic device connected to the magnet-retaining portion and having an outer surface displaced frontwardly from the outer surface of the grip portion; a cover pivotally connected to another end of the frame, the cover including a lifter configured to contact an end of the magnet-retaining portion and cause an end of the magnet-retaining portion to pivot about the frame when the cover is lifted and the lifter is rotated, thereby moving the first end of the magnet-retaining portion and the magnetic device in a rear-to-front direction; and an item-holding portion.

Detachable magnet device

Disclosed are methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Methods of using ultrasound waves for sonodynamic therapy

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as drugs, may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

Methods of treating tumors with drugs

Disclosed are methods of using planar acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of flat piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a modulated planar acoustic wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Methods of using planar acoustic waves for non-invasive sonodynamic therapy

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Zero vergence ultrasound waves for sonodynamic therapy

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

Methods of treating tumors with pro drugs

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves that do not converge and do not diverge. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Devices for detachable attachment to a ferromagnetic object and/or surface are disclosed. The device may comprise a core housing defining a pocket, a magnet disposed in the pocket, and a baseplate fixed to the magnet sheet assembly. The baseplate may include a pivot portion that engages a corresponding portion of the core housing to form a hinge joint such that the baseplate and the magnetic sheet assembly selectively pivot about a pivot axis of the hinge joint relative to the core housing. The camming mechanism may apply a camming force to a portion of the baseplate and the camming force may urge the magnet and the baseplate to pivot about the pivot axis of the hinge joint.

Growing community of inventors

Minneapolis, MN, United States of America

Braden Eliason