Cellphire, Inc.

Braden Carl Ishler

Keith Andrew Moskowitz

Amber Nicole Lee

William Matthew Dickerson

Glen Michael Fitzpatrick

Rafael Jorda

Narendra Nath Tandon

Stephen Edward Amos

Michael Alexander Mathews

Joshua Donald Montgomery

Daniel Allen Sheik

Shan Xu

In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

Thrombosomes as an antiplatelet agent reversal agent

Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

Platelet derivative compositions, and pluralities of containers containing same

Methods using freeze-dried platelet derivative compositions for restoring hemostasis in a subject

Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

Treatment of von Willebrand disease

Methods of treating bleeding in a subject treated with an antiplatelet agent

Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Materials and methods for producing blood products

Growing community of inventors

Gaithersburg, MD, United States of America

Braden Carl Ishler