Walter and Eliza Hall Institute of Medical Research

Msd R&d (China) Co., Ltd.

Merck Sharp + Dohme Corp.

Merch Sharpe & Dohme LLC

Bionomics Inc.

Msd R&d Co., Ltd.

Brad Sleebs

Bin Hu

John A McCauley

David Brian Olsen

Jonathan Bayldon Baell

Bernard Luke Flynn

Zhuyan Guo

Manuel De Lera Ruiz

Michael J Kelly, Iii

Nurul Quazi

Ian Phillip Street

Zhiyu Lei

Dongmei Zhan

Lianyun Zhao

Chinh Thien Bui

Alan F Cowman

Paola Favuzza

Jennifer K Thompson

Tony Triglia

Cailing Zhang

John A Mccauley

Chinh Thein Bui

Michael J Kelly Iii

Methods of treating malaria comprising administration of compounds of Formula (I') or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating ainfection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

Antimalarial agents

The present invention provides methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for the possible inhibition of plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating ainfection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

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Bundoora, Australia

Brad Sleebs