Ortho-mcneil Pharmaceutical Corp.

Other

Johnson & Johnson Consumer Companies, Inc.

Janssen Pharmaceutica Nv

Sk Biopharmaceuticals Co., Ltd.

Boyu Zhao

Carlos Plata-Salaman

Allen B Reitz

Roy E Twyman

Magdalena G Eisinger

Virginia L Smith-Swintosky

Louis J Fitzpatrick

Kevin Pan

Daniel H Lee

Robert T Gordon

Yong Moon Choi

Mark J Macielag

James C Lanter

Ellen Codd

Alfonzo D Jordan

H Steve White

Suying Zhang

Ramesh M Kanojia

Carlos R Plata-Salaman

Gerald P Novak

Robert Gordon

The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

1,2,4-thiadiazolium derivatives as melanocortin receptor modulators

The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

1,2,4-thiadiazole derivatives as melanocortin receptor modulators

This invention is directed to a method for preventing or treating bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) or enantiomeric mixture wherein one enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R, R, Rand Rare independently selected from the group consisting of hydrogen and C&#x2013;Calkyl; wherein C&#x2013;Calkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C&#x2013;Calkyl, C&#x2013;Calkoxy, amino, nitro and cyano).

Carbamate compounds for use in preventing or treating bipolar disorder

This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):  wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R, R, Rand Rare independently selected from the group consisting of hydrogen and C&#x2013;Calkyl; wherein C&#x2013;Calkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C&#x2013;Calkyl, C&#x2013;Calkoxy, amino, nitro and cyano).

Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain

This invention is directed to a method for preventing or treating anxiety disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II):wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R, R, R, R, Rand Rare independently selected from the group consisting of hydrogen and C-Calkyl; wherein C-Calkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C-Calkyl, C-Calkoxy, amino, nitro and cyano).

Carbamate compounds for use in preventing or treating anxiety disorders

Carbamate compounds for use in the treatment of pain

Neurotrophic pyrrolidines and piperidines, and related compositions and methods

Carbamate compounds for use in preventing or treating movement disorders

Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods

Carbamate compounds for use in preventing or treating psychotic disorders

Growing community of inventors

Lansdale, PA, United States of America

Boyu Zhao