Purdue Research Foundation

Methodist Hospital of Indiana, Inc.

Clarian Health Partners, Inc.

Boyle Cheng

Stephen Francis Badylak

Bryan A Whitson

Michael C Hiles

Umesh H Patel

Klod Kokini

A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.

Perforated submucosal tissue graft constructs

Method of repairing perforated submucosal tissue graft constructs

Multilayered submucosal graft constructs and method for making the same

A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.

Large area submucosal tissue graft constructs and method for making the

Large area submucosal tissue graft constructs

Growing community of inventors

Greeley, CO, United States of America

Boyle Cheng