Cosmosid Inc.

The United States of America

Boyd Thomas Livingston

Rita R Colwell

John P Jakupciak

Nur A Hasan

Douglas M Brenner

David Jakupciak

Benjamin M Bielefeld

Tad P White

Michael A Wertheimer

J William Pendergrass

Thomas H Monroe

Tom Cebula

Huai Li

The present invention relates to systems and methods capable of characterizing populations of organisms within a sample. The characterization may utilize probabilistic matching of short strings of sequencing information to identify genomes from a reference genomic database to which the short strings belong. The characterization may include identification of the microbial community of the sample to the species and/or sub-species and/or strain level with their relative concentrations or abundance. In addition, the system and methods may enable rapid identification of organisms including both pathogens and commensals in clinical samples, and the identification may be achieved by a comparison of many (e.g., hundreds to millions) metagenomic fragments, which have been captured from a sample and sequenced, to many (e.g., millions or billions) of archived sequence information of genomes (i.e., reference genomic databases).

Direct identification and measurement of relative populations of microorganisms with direct DNA sequencing and probabilistic methods

A key escrow encryption method, where two users each have secret encryption keys and corresponding public encryption keys. One user receives the public encryption keys of the other user and generates a first datum based on them, an identifier of the other user, the secret encryption keys and identifier of the user, and an access restriction. The user generates a second datum based on the first datum and another access restriction. The user generates a key based on the first and second datums. The user encrypts a message using the key and sends it to the other user. Key escrow is included by requiring each user to distribute its secret encryption keys among escrow agents. The escrow agents transform, sign, and transmit it to a certifying authority. The certifying authority signs and publishes it as user's public key certificate. To communicate, a user retrieves the certificate of the other user, forms a key, encrypts a message, and transmits it to the other user. The other user retrieves the certificate of the user, forms the key, and decrypts the message. A key encryption key scheme may be used. A third party may intercept the message, receive authorization, receive portions of the key from the escrow agents, recover the key, and recover the message. A data recovery scheme may be used.

Method of public key cryptography that includes key escrow

Growing community of inventors

Columbia, MD, United States of America

Boyd Thomas Livingston