Southern Illinois University

Vanderbilt University

University of California

Duke University

Lawrence Berkeley National Laboratory

Boyd M Goodson

Eduard Y Chekmenev

Roman V Shchepin

Fan Shi

Alexander Pines

Gil Navon

Thomas F Budinger

Stephan Appelt

Angelo Bifone

Rebecca Taylor

Toomas Room

Tanja Pietrass

Aaron M Coffey

Yi-Qiao Song

Roberto Seydoux

Warren S Warren

Thomas Theis

Milton L Truong

Danila A Barskiy

Bryce E Kidd

Quinn A Best

Yong Gao

Yuqing Hou

Ping He

Igor V Koptyug

Kirsten A Groome

Kirill V Kovtunov

Jonathan Gesiorski

Max E Gemeinhardt

Miranda Limbach

Jamil A Mashni

The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

Cleavable agents

The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.

Removal of homogeneous catalysts from NMR/MRI agents hyperpolarized via sabre or PHIP

Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.

Method for creating hyperpolarization at microTesla magnetic fields

Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.

Method for creating hyperpolarization at microtesla magnetic fields

Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.

Water soluble catalysts for NMR/MRI enhancement

Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.

Heterogeneous catalysts for NMR/MRI enhancement via signal amplification by reversible exchange (SABRE)

Composition and method for surface-functionalized SPION-based agents. Such agents can provide highly pH-sensitive MRI contrast in tissue.

PH-sensitive imaging agents

The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis

Enhancement of NMR and MRI in the presence of hyperpolarized noble gases

Growing community of inventors

Carbondale, IL, United States of America

Boyd M Goodson