Boehringer Ingelheim International Gmbh

Other

Boehringer Ingelheim (canada) Ltd.

Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Pharma Gmbh & Co Kg

Bounkham Thavonekham

Bruno Simoneau

Anne-Marie Faucher

Jean Rancourt

Pierre Louis Beaulieu

Christiane Yoakim

Timothy A Stammers

Youla S Tsantrizos

Karl D Hargrave

Jeffrey O'Meara

Christian Brochu

Serge R Landry

Christine A Grygon

Martin Poirier

Catherine Chabot

James J Crute

Gulrez Fazal

Sebastien Morin

Patrick Deroy

Alexandre Gagnon

Eric Malenfant

William W Ogilvie

Stephen Kawai

Sylvie Goulet

Julie Naud

Rene Coulombe

René Coulombe

Robert Déziel

Tim Stammers

J James Crute

Jeffrey O'MEARA

Compounds of formula (I): wherein Ar, X, R, R, Rand Rare as defined herein. The compounds are useful as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV.

Non-nucleoside reverse transcriptase inhibitors

An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R, R, R, R, R, R, R, R, R, and Rare as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.

Viral polymerase inhibitors

Compounds of formula I: wherein X, R, R, Rand Rare defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

Disclosed herein are compounds of formula Ar&#x2014;X&#x2014;W&#x2014;Arwherein Arand Arrepresent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)-N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.

Non nucleoside reverse transcriptase inhibitors

A compound, represented by formula (I): wherein A, B, R, R, R, R, R, R, R, and Rare as defined herein, or an enantiomer, diastereoisomer or tautomer thereof, including a salt, ester or derivative thereof, as an inhibitor of HCV NS5B polymerase.

Compounds represented by formula I: wherein Ris H, halogen, (C)alkyl, O(C)alkyl, and haloalkyl; Ris H or (C)alkyl; Ris H or (C)alkyl; Ris (C)alkyl, (C)alkyl(C)cycloalkyl, or (C)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.

This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.

Anti-herpesvirus compounds and methods for identifying, making and using same

This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives

Antiherpes virus compounds and methods for their preparation and use

Anti-herpesvirus compounds and methods for identifying, making and using

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Longueuil, Canada

Bounkham Thavonekham