Centre National De La Recherche Scientifique

Bio-rad Innovations

Centre Hospitalier Régional Universitaire De Lille

Université Lille 2 - Droit Et Santé

Centre Hospitalier Universitaire De Lille

Université Sciences Technologies Lille

Centre Hospitalier Regional Universitaire (chru)

Université De Droit Et Santé De Lille

Bio-rad Europe Gmbh

Université De Lille 2 Droit Et Santé

Centre Hospitalier Régional Et Universitaire De Lille

Boualem Sendid

Daniel Poulain

Reynald Chevalier

Pierre Sinay

Jean-Frédéric Colombel

Jacques Esnault

Jean-Maurice Mallet

Chantal Fradin

Thierry Jouault

Yann Guerardel

Sebastien Damiens

Pierre-André Trinel

Marc Charles Victor Tabouret

Nadine Francois

Sébastien Damiens

Fradin Chantal

The present invention concerns an in vitro method for diagnosing invasive candidiasis (IC) in a subject which comprises detecting the presence of aglycan and detecting the presence of antibody directed against a protein selected from the group consisting of fructose bisphosphate aldolase (Fba1), enolase 1 (Eno1), heat shock protein 90 (Hsp90), hyphal wall protein (Hwp1), and mannoprotein 65 (Mp65) in a blood, plasma or serum sample of the subject. The invention also relates to a method of determining a suitable treatment regimen for a patient and to a kit for implanting the methods described herein.

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A method for the in vitro diagnosis of an invasive fungal infection by MALDI-TOF mass spectrometry. The method involves, providing a liquid biological sample from a mammal, said biological sample containing, in particular, proteins and/or lipids and/or salts and/or polysaccharides and/or oligosaccharides and/or monosaccharides capable of forming complexes with said proteins and/or lipids and/or salts; treating said sample with biological liquid so as to extract said polysaccharides and/or oligosaccharides and/or monosaccharides; determining, by MALDI-TOF mass spectrometry, whether or not there is present among said extracted polysaccharides, oligosaccharides and/or monosaccharides, at least one given compound of interest coming from said fungal microorganism and chosen from polysaccharides, oligosaccharides and monosaccharides; and deducing, if said given compound of interest is present in said sample, that said mammal is suffering from an invasive fungal infection.

In vitro diagnostic method for an invasive fungal infection using MALDI-TOFF mass spectrometry

A pharmaceutical composition including a therapeutically effective amount of at least one oligomannoside produced by chemical synthesis which is homologous to a wall oligomannoside of an infectious organism or pathogen, or a derivative thereof, and a pharmaceutically acceptable vehicle.

Synthetic oligomannosides, preparation and uses thereof

Growing community of inventors

Loos, France

Boualem Sendid