Richter Gedeon Nyrt.

Richter Gedeon Vegyeszeti Gyar Rt

Botond Penke

Gábor Balogh

Ibolya Horváth

Ferenc Fülöp

Zsolt Török

Sándor Bernáth

Ákos Hunya

Lajos Kovacs

Miklos Low

László Vígh

Gyorgy Dobo

Vince Varro

Laszlo Varga

Lajos Balaspiri

Geza Ivanyi

László Vigh

Judit Low, Nee Kaloczy

Kalman Kovacs

Peter Pallai

Janos Lonovics

The invention provides 1,4-dihydropyridine derivatives of formula (I) wherein Ris optionally substituted Caryl group or 5 to 6 membered heteroaryl group comprising 1 to 3 nitrogen atoms or other heteroatoms like oxygen and sulphur, and combinations thereof; Rand Rare independently hydrogen or Calkyl group; Rand Rare independently hydrogen, Calkyl group optionally substituted with amino, mono- or di(Calkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with Calkyl group or Calkoxy group; Ris Calkyl, Ccycloalkyl, CcycloalkylCalkyl or arylCalkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters and prodrugs thereof for use in the therapeutic or prophylactic treatment of a disorder mediated by heat shock proteins. 

1,4-dihydropyridine derivatives with HSP modulating activity

1,4-dihydropyridine derivatives with Hsp modulating activity

A process for the preparation of L-aspartyl-(O-sulfato-L-tyrosyl)-L-methionyl-glycyl-L-tryptophyl-L-methion yl-L-aspartyl-L-phenylalanine amide, which comprises treating the protected octapeptide amide of the general formula (II) ##STR1## wherein X is BOC, Cbz or Ddz,

Process for the preparation of the cholecystokinin-pancreozymin

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Szeged, Hungary

Botond Penke