American Cyanamid Company

Bosco S Wang

Ian C Hart

Hong-Ming Shieh

John S Logan

William R Baumbach

Martin John Corbett

Araceli L Lumanglas

Homayoun Sadeghi

Vijay G Nair

V M Ruszala-Mallon

Ramson B Conrow

The present invention is directed to antibodies, in particular monoclonal antibodies, of porcine somatotropin (pST). When these antibodies are administered together with pST, the growth of vertebrates is greater than that achieved with the administration of pST alone. The invention is also directed to an increase in the growth of vertebrates which persists over long periods when an antibody to a somatotropin is administered together with such somatotropin.

Immunologic enhancement of the somatogenic effect of somatotropin with

An isolated polypeptide corresponding to the epitope of porcine somatotropin is provided by this invention as well as methods of enhancing the growth of an animal by administering to the animal this polypeptide in compositions.

Biologically active porcine somatotropin polypeptides and methods of

The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may be used alone to enhance the growth of animals, or may be used together with somatotropin to potentiate the effect of somatotropin in animals. The antibodies may also be used to assay the level of somatotropin binding protein of animals.

Antibodies specifically recognizing somatotropin binding proteins

The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may also be used to assay the level of somatotropin binding protein of animals.

Monoclonal antibodies that specifically bind somatotropin binding

This invention is directed to peptide fragments of porcine somatotropin (pST) which are used to generate epitope-specific anti-pST antibodies. When such antibodies are administered with pST to warm-blooded animals, the growth enhancing activity of pST is potentiated.

Enhancement of porcine somatotropin activity

This invention is directed to the generation of hybridomas and the monocot-specific monoclonal antibodies prepared from those hybridomas against the acetohydroxyacid synthase enzyme. The monoclonal antibodies are useful to isolate and purify the enzyme. The invention is also directed to peptides corresponding to fragments of the enzyme which then are used to generate the monoclonal antibodies.

Monocot-specific monoclonal antibodies against acetohydroxyacid synthase

This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.

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Cranbury, NJ, United States of America

Bosco S Wang