Plant Research International B.v.

Institute Jozef Stefan

University of Ljubljana

Labena D.o.o.

Borut Strukelj

Hendrik Jan Bosch

Willem Johannes Stiekema

Mojca Lunder

Maarten Anthonie Jongsma

Vito Turk

Matjaz Ravnikar

Ales Berlec

Boris Ceh

Brigita Lenarcic

Kristina Gruden

The present invention relates to microorganisms that express, or have attached to their surface, a TNF&#x3b1; binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNF&#x3b1; and therefore reducing the content of free TNF&#x3b1; and alleviating its pro-inflammatory effects in the gut. The invention also relates to the use of such microorganisms as medicament in the treatment of inflammatory bowel disease.

Modified food grade microorganism for treatment of inflammatory bowel disease

A method of protecting a plant or part of a plant from insect or nematode infestation is disclosed herein. The method includes the steps of: inserting into the genome of cells or tissue from a plant a sequence coding for equistatin operably linked to a promoter sequence active in the plant to cause expression of the protein at levels which provide an insect or nematode controlling amount of the protein; and regenerating resistant whole plants from the cells or tissue. Also disclosed is a transgenic plant or its sexual progeny which is resistant to attack by one or more insects or nematodes having digestive cysteine proteases. Also disclosed is an expression vehicle that includes a promotor effective to promote expression of a downstream coding sequence in plant cells, the expression vehicle being effective to express in plant cells insect controlling amounts of equistatin.

Method for plant protection against insects or nematodes by transformation with a nucleic acid encoding equistatin

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Ljubljana, Slovenia

Borut Strukelj