The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of Dundee

Masaryk Memorial Cancer Institute

Univerzita Palackeho V Olomouci

Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky

Ustav Experimentalni Botaniky Av Cr, V.v.i.

Bioapex, S.r.o.

Vojtesek, Borivoj

Borivoj Vojtesek

Curtis C Harris

David Philip Lane

Jean-Christophe Bourdon

Izumi Horikawa

Kaori Fujita

Miroslav Strnad

Karel Dolezal

Marek Zatloukal

David P Lane

Vladimir Krystof

Libor Havlicek

Igor Popa

René Lenobel

Stefaan Werbrouck

Dana Hradecká

Stjepan Uldrijan

Petr Mlejnek

Dana Hradeck

The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.

Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer

Therapeutic applications of P53 isoforms in regenerative medicine, aging and cancer

The invention relates to new substituted 6-(2-aminobenzylamino)purines, represented by the general formula I, which can be used in CDK inhibition, in particular, in the treatment of viral infections and diseases involving cell proliferation. The invention further includes pharmaceutical preparations containing substituted 6-(2-aminobenzylamino)purines.

Substituted 6-(2-aminobenzylamino)purine derivatives, their use as medicaments and preparations containing these compounds

The invention concerns novel substitution derivatives of N-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.

[object Object]

Growing community of inventors

Modrice, Czechia

Borivoj Vojtesek