The Children's Hospital of Philadelphia

Drexel University

Ben-gurion University of the Negev Research and Development Authority

Université Joseph Fourier - Grenoble 1

Boris Polyak

Robert J Levy

Ivan Alferiev

Michael Chorny

Ilia Fishbein

Gennady Friedman

Darryl Williams

Serge Cosnier

Robert Steven Marks

Elena Rodica Ionescu

Khalil Abu-Rabeah

Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

Uniform field magnetization and targeting of therapeutic formulations

A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.

Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex

The present invention relates to a new hydrogel functionalized with a polymerizable moiety, the polymerized hydrogels, films and gels comprising the same and their use for cells, proteins, DNA or other molecules encapsulation, including use as biosensors or bioreactors.

Hydrogel functionalized with a polymerizable moiety and their uses as biosensors or bioreactors

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Philadelphia, PA, United States of America

Boris Polyak