Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Bristol-myers Squibb Compnay

Eisai Inc.

Boris M Seletsky

Mark Spyvee

Wanjun Zheng

Shawn Schiller

James J Kowalczyk

Hu Yang

Galina Kuznetsov

Melvin J Yu

Bruce A Littlefield

Murray J Towle

Toshihiko Kaneko

Seiichi Kobayashi

Kenzo Muramoto

Kouichi Kikuchi

Motohiro Soejima

Ieharu Hishinuma

Heather Davis

Yimin Jiang

André Lescarbeau

Norihito Ohi

Monica H Palme

Xiang-Yi Li

Bruce Decosta

Fabian Gusovsky

Hiromitsu Yokohama

Marc Pesant

Ye Yao

Yan (Janet) Zhao

Lynda Tremblay

Jane Daun

Francis Gerard Fang

Deqiang Niu

T G Murali Dhar

John V Duncia

Robert J Cherney

Daniel S Gardner

Ramesh Kumar Sistla

Manoranjan Panda

Venkatram Reddy Paidi

Srinivasan Thangathirupathy

Julio Hernan Cuervo

Xiao Zhu

Kumaravel Selvakumar

Silvio A Campagna

Alyssa H Antropow

Piyush Agarwal

Arul Mozhi Subbiah Karuppiah

Jalathi S Nair

Guobin Miao

Zhengdong Zhu

Paul E Gormisky

Audrey Graham Ross

Ooha Morampudi

Krishna Mahadevu

Tirupathi Rao Alajangi

Mallikarjun Reddy Sura

Vijaya Kumar Cm

Monica Palme

wherein and X-Xand R-R, along with other variables are as defined herein. The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.

Heterocyclic PAD4 inhibitors

The present invention provides compounds having formula (I): 

Deazapurines and uses thereof

Hemiasterlin derivatives and uses thereof in the treatment of cancer

The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.

Methods and compositions for use in treating cancer

The present invention provides compounds having formula (I):  and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R-R, X, X, R, Q, and n are as defined herein.

The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.

The invention relates to compounds of formula I: along with pharmaceutical compositions containing the same and methods of use thereof for the treatment of autoimmune disease.

Imidazoazepinone compounds

As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

Hemiasterlin derivatives and uses thereof

The present invention provides compounds having formula (I), wherein R, R, Rand n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally 

The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R&#x2013;R, X, X, R, Q, and n are as defined herein.

Intermediates in the preparation of macrocyclic analogs

Intermediate compounds for preparing macrocylcic analogs

Growing community of inventors

Andover, MA, United States of America

Boris M Seletsky