Datascope Investment Corporation

The Penn State Research Foundation

Tc1 LLC

Thoratec Corporation

Lifecuff Technologies Inc.

The Texas A&M University System

Empire Technology Development LLC

Corinnova Incorporated

Infarct Reduction Technologies Inc.

Endovascular Technologies, Inc.

Tci Incorporated

Scientific Resources, Inc.

Corlnnova Incorporated

Leschinsky, Boris

Boris Leschinsky

Mark W McBride

Robert L Campbell

Thomas M Mallison

Justin M Walsh

Robert F Kunz

James P Runt

David A Boger

Gregory P Dillon

Stephen A Hambric

Jonathan R Williams

Robert B Schock

John C Criscione

Mark A Follman

Jeffrey Urbanski

Christina M Bolch

Sidney Wolvek

Shrenik Daftary

Robert L Wilcox

Clifford E Schwartz

Dennis Goupil

Keif M Fitzgerald

Daniel A Walters

William James Harrison

Phyllis Yuen

Dennis I Robbins

Lawrence Saper

Saurabh Biswas

Lewis D Harrison

Michael R Moreno

Abe Abramovich

Adam Roslund

Helio Marcos Ribeiro

Jeffrey McGinley

Stanton Rowe

Mikhail Leschinsky

Thomas A Moore

Steven A Hambric

A catheter blood pump includes a cannula with an expandable central portion having a proximal end, a distal end and a blood flow conduit therebetween. A flexible inlet portion at the distal end is provided with a plurality of spaced apart inlet struts configured to prevent an obstruction from entering, and a flexible outlet portion is provided with a plurality of spaced apart outlet struts operative to reduce a swirl velocity of blood, wherein the plurality of spaced apart inlet struts and the plurality of spaced apart outlet struts are fabricated from a collapsible shape memory material.

Catheter blood pump heart assist device

An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.

Heart assist device with expandable impeller pump

The present invention provides methods, systems, kits, and cardiac compression devices that have both passive chambers and active chambers to improve heart function.

Cardiac compression device having passive and active chambers

An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

Expandable impeller pump

A system for automated delivery and monitoring compliance for repeated remote ischemic conditioning treatments incudes at least one device for automated delivery of the therapy and at least one communications module to collect and record usage data. Reports of subject compliance with a predetermined schedule of therapy delivery is transmitted to the central database and a prescribing physician.

Systems and methods for delivery of repeated remote ischemic conditioning and monitoring compliance

Methods for adaptive cuff inflation for the purposes of occluding a limb of a subject include inflating a cuff to a pressure at or above limb occlusion pressure and periodically deflating the cuff to detect amplitude of oscillometric oscillations reaching or exceeding a predetermined threshold, whereby indicating that the cuff pressure has reached an updated systolic blood pressure. Selecting the cuff to be wide enough to define limb occlusion pressure at or below the systolic blood pressure assures that this maneuver does not compromise cessation of blood flow to the limb. Devices are disclosed configured to operate in at least two of the following three operating modes: a tourniquet mode, a remote conditioning mode and a blood pressure monitoring mode.

Multi-mode inflatable limb occlusion devices and methods

The present invention provides an implantable cardiac compression device comprising: an inflatable cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, a channel that connects the inflatable cardiac compression jacket and an expandable fluid reservoir configured to contain a fluid when displaced compresses the inflatable cardiac compression jacket, and a fluid driver operably connected to the inflatable cardiac compression jacket and to the expandable fluid reservoir, wherein the fluid driver is configured to inflate the cardiac compression jacket and to deflate the expandable fluid reservoir during systole of the heart; said driver is further configured to deflate the cardiac compression jacket and to inflate the expandable fluid reservoir during diastole of the heart.

Fully implantable direct myocardium assist device

The present invention includes a device and method for a self-expanding framework device adapted to facilitate the deployment of an extra-cardiac device. The device includes a deployment tube and a self-expanding wire framework having a structure that results in the self-expanding wire framework circumferential flaring motion and bending outwardly to advance around the heart.

Self-expanding heart assist device

Treatment methods are described using blood collected from a donor after subjecting thereof to remote conditioning such as remote ischemic conditioning via several episodes of short-term limb occlusion. Blood containing remote conditioning substances or a biologically active preparation containing such substances may be stored and used at a future time to afford a health benefit to the treatment subject. Extraction of remote conditioning substances may be done extracorporeally using dialysis or other blood processing methods following by returning of blood to the donor. Extraction of remote conditioning substances may be done during the time periods of their maximum presence in donor blood.

Treatment methods and biologically active preparations using blood of a donor subjected to remote conditioning

The present invention provides a combined direct cardiac compression and aortic counterpulsation device comprising: an inflatable direct cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, and a driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to inflate said direct cardiac compression jacket and to deflate said aortic counterpulsation chamber during systole of the heart; said driver is further configured to deflate said direct cardiac compression jacket and to inflate said aortic counterpulsation chamber during diastole of the heart.

Fully implantable direct cardiac and aortic compression device

Growing community of inventors

Mahwah, NJ, United States of America

Boris Leschinsky