Micromass UK Limited

Boris Kozlov

John Brian Hoyes

Keith George Richardson

Jeffery Mark Brown

David John Langridge

Irina Vasileva

Vasiliy Makarov

A Time of Flight mass analyser is disclosed comprising: at least one ion mirrorfor reflecting ions; an ion detectorarranged for detecting the reflected ions; a first pulsed ion acceleratorfor accelerating an ion packet in a first dimension (Y-dimension) towards the ion detectorso that the ion packet spatially converges in the first dimension as it travels to the detector; and a pulsed orthogonal acceleratorfor orthogonally accelerating the ion packet in a second, orthogonal dimension (X-dimension) into one of said at least one ion mirrors

Time of flight mass analyser with spatial focussing

A method of self-calibrating a mass spectrometer or mass spectral data is disclosed. At least some first observed mass to charge ratios are matched with or against a comprehensive reference set of possible or predicted elemental compositions having known precise mass to charge ratios. One or more calibration parameters of a calibration routine are then adjusted so as to optimise the match between one or more of the first observed mass to charge ratios and the corresponding known precise mass to charge ratios of one or more possible or predicted elemental compositions contained within the reference set.

Self-calibration of high resolution mass spectrum

An electrode assembly, such as for an ion mirror, comprising: a first layer having a plurality of electrodes that are separated by one or more gaps; a second layer arranged to cover said one or more gaps and prevent electric fields passing through said one or more gaps, said second layer having electrically conductive material located to be coincident with said one or more gaps in the first layer.

Electrode assembly for mass spectrometer

A mass spectrometer comprising: an ion energy filterarranged and configured to filter ions according to their kinetic energy and so as to only transmit ions having a component of kinetic energy in a first dimension (z-dimension) that is within a selected range; and a multi-reflecting time of flight mass analyser or mass separatorhaving an ion accelerator, and two gridless ion mirrorsthat are elongated in the first dimension (z-dimension) and configured to reflect ions multiple times in a second orthogonal dimension (x-dimension), wherein the ion acceleratoris arranged to receive ions from the energy filterand accelerate the ions into one of the ion mirrors

Multi-reflecting time of flight mass analyser

A mass spectrometer comprising: a multi-reflecting time of flight (MRTOF) mass analyser or mass separator having two gridless ion mirrorsthat are elongated in a first dimension (Z-dimension) and configured to reflect ions multiple times in a second orthogonal dimension (X-dimension) as the ions travel in the first dimension; the spectrometer configured to operate in: (i) a first mode for ions having a first rate of interaction with background gas molecules in the mass analyser or separator, such that the ions are reflected a first number of times between the ion mirrors; and (ii) a second mode for ions having a second, higher rate of interaction with background gas molecules in the mass analyser or separator, such that ions are reflected a second, lower number of times between the ion mirrors

A Time of Flight mass analyser is disclosed comprising: at least one ion mirror (() for reflecting ions; an ion detector () arranged for detecting the reflected ions; a first pulsed ion accelerator () for accelerating an ion packet in a first dimension (Y-dimension) towards the ion detector () so that the ion packet spatially converges in the first dimension as it travels to the detector (); and a pulsed orthogonal accelerator () for orthogonally accelerating the ion packet in a second, orthogonal dimension (X-dimension) into one of said at least one ion mirrors ().

A method of filtering ions () is disclosed comprising: providing an ion filter () having an ion entrance, an ion exit and a plurality of electrodes (); applying an AC and/or RF voltage to at least a first electrode so as to generate a pseudo-potential barrier; and urging ions towards the pseudo-potential barrier as they travel from the entrance to the exit whilst maintaining the ion filter () at a pressure such that first ions are repelled by the pseudo-potential barrier and so are transmitted through the filter to said exit, whereas second ions having substantially the same mass to charge ratio as the first ions but a lower mass are not capable of being repelled by the pseudo-potential barrier and reaching said exit.

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Manchester, United Kingdom

Boris Kozlov