Mars, Incorporated

Senomyx, Inc.

Xenon Pharmaceuticals Inc.

Boris Klebansky

Richard Masten Fine

Matthew Ronald Gibbs

Scott Joseph McGrane

Andrew John Taylor

Xiaodong Li

Catherine Tachdjian

Albert Zlotnik

Guy Servant

Qing Chen

Xiao-Qing Tang

Feng Zhang

Marketa Rinnova

Xinshan Kang

Haitian Liu

Mark Zoller

Sara Werner

Donald Karanewsky

Shaoyi Sun

Vincent Darmohusodo

Hong Zhang

Vishnumurthy Kodumuru

Joseph R Fotsing

Sara L Adamski-Werner

Jeffrey Robert Hammaker

Goran Petrovic

Jeffrey Yamamoto

Rachel D A Kimmich

Michael D Winther

Heinz W Gschwend

Daniel F Harvey

Mark Gray-Keller

Wenbao Li

Sara Adamski-Werner

Rachel DA Kimmich

Donald S Karanewsky

Scott Joseph Mcgrane

Rachel Da Kimmich

Jian-min Fu

The presently disclosed subject matter relates to methods of screening raw materials and pet food products to manufacture a palatable pet food product. The presently disclosed subject matter also relates to methods for identifying compounds that modulate the activity and/or expression of a taste receptor.

Screening methods using GPRC6A taste receptors and pet food products and compositions prepared using the same

The present disclosure provides methods for identifying compounds that modulate the activity and/or expression of GPR92, wherein said compounds can be incorporated into flavor compositions that can be used to modify the taste and/or palatability of pet food products. In certain non-limiting embodiments, the present disclosure provides a method for identifying a composition that modulates the activity of a GPR92 receptor comprising (a) contacting a test agent with a GPR92 receptor, (b) determining the activity of the GPR92 receptor, and (c) selecting as the composition, a test agent that increases the activity of the GPR92 receptor.

Methods for identifying modulators of GPR92

Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

Methods for modulating taste receptors

Methods for identifying compounds that modulate the activity and/or expression of a calcium-sensing receptor, wherein said compounds can be incorporated into flavor compositions that can be used to modify the kokumi taste and/or palatability of pet food products.

Methods for identifying modulators of calcium-sensing receptors

The present invention relates to a method of identifying a compound that binds to or modulates the activity of one or more polypeptides encoding one or more receptors that are involved in the detection and perception of fatty acids.

Methods for increasing palatability of pet foodstuff

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Modulation of chemosensory receptors and ligands associated therewith

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

The present invention provides, in part, substituted thieno[2,3-d]pyrimidines and methods of contacting compositions with such compounds to enhance the sweet taste of said compositions.

Methods of enhancing sweet taste of compositions using substituted thieno{2,3-D}pyrimidines

The present invention provides compounds including substituted thienopyrimidinone derivatives of Formula (IIc) as ligands for modulating chemosensory receptors: These compounds are useful as sweet taste enhancers in comestible or medicinal compositions. The present invention also provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors

Novel compounds useful in the treatment of, prevention of or protection against diseases and/or conditions related to metabolic syndrome and lipid metabolism, especially diseases of fatty acid and cholesterol metabolism, such as those mediated by stearoyl-CoA desaturase, are disclosed along with methods of employing said compounds for such uses.

Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents

Growing community of inventors

Demarest, NJ, United States of America

Boris Klebansky