Queen's University at Kingston

Boris I Gorine

Xianqi Kong

Walter A Szarek

Richard J Riopelle

Gregory R J Thatcher

Gregory R Thatcher

Kimberly E Dow

Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

Phosphono-carboxylate compounds for treating amyloidosis

Nerve process growth modulation can be achieved using derivatized cyclodextrins. Processes for making sulfated and aminated .beta.-cyclodextrin derivatives are also described in which a compound of the formula R'.sub.2 NCH X'.sup.+ X'.sup.- where R.sup.- is an alkyl containing 1-5 carbon atoms and X is selected from bromine and iodine is used to halogenate the cydodextrin.

Nerve process growth modulators

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Kingston, Canada

Boris I Gorine