Ctc Bio, Inc.

Hyundai Motor Company

Kia Motors Corporation

Other

CTO Bio, Inc.

Jin Yang Pharm Co., Ltd.

Bong-Sang Lee

Hong Ryeol Jeon

Su-Jun Park

Do-Woo Kwon

Hong-Ryeol Jeon

Cheol-Soo Park

Dae-Kwang Kim

Jiyeong Han

Seong-Shin Kwak

Myeongcheol Kil

Dong-Suk Chae

Dong-Jin Lee

Min Seop Kim

Woo-Tae Kim

Byung-Soo Lee

Hyun-Jung Park

Bong-Geun Cha

Jung-Hwa Kim

Jun-Ki Kim

Seung-Woo Lee

Seung Kyun Kim

Jun-Sik Park

Gyu-Han Hwang

Jae-Joon Choi

Sun-Ahe Lee

Se-Geun Yu

Yun Jin Sung

Dong-Ryun Oh

Jeong-Seo Park

Se-Heum Oh

Seul Ki Meang

Ji-yeong Han

Soung-Baek Jang

Hyun-Il Kim

Jeong-Hwa Yoo

Myeong-Cheol Kil

Disclosed is a capsule filling apparatus. The capsule filling apparatus includes a supplying member configured to supply a tablet; a moving member configured to move the tablet supplied from the supplying member in a preset direction; a catching member configured to catch the tablet moved by the moving member by suction and insert the caught tablet into a capsule; and a capsule accommodating member located below the catching member so that the capsule is accommodated therein.

Capsule filling apparatus

The present disclosure relates to an orally administered pharmaceutical formulation containing an inclusion complex formed as varenicline or a pharmaceutically acceptable salt thereof is included in cyclodextrin. The pharmaceutical formulation can improve convenience of medication by effectively masking the bitter taste of the drug and the irritation during swallowing, can provide the oxidation stability of varenicline and can improve the solubility of the drug.

Preparation, comprising inclusion complex of varenicline or pharmaceutically acceptable salt thereof, for oral administration

The present disclosure relates to a film formulation for oral administration, containing tadalafil free base and a method of preparing the same, and a film may be provided with maximized dispersion stability of tadalafil free base in the film by the addition of a dispersion stabilizing agent in small amounts without unique fragrance or favor that may appear when other dispersion stabilizing agents known in the art are used, and an extremely low likelihood that a reagglomeration phenomenon of tadalafil free base particles will occur, and an amount of bubbles generated may be significantly reduced during a production process.

Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer

A vehicle thermal management system is provided that includes an integrated thermal management (ITM) valve having a coolant outlet flow path that is connected to each of heat exchangers, which include one or more among a coolant inlet connected to an engine coolant outlet of an engine and into which coolant flows, a heater core, an EGR cooler, an oil warmer, and an ATF warmer, and a radiator and through which the coolant is distributed. A water pump is disposed at the front end of an engine coolant inlet of the engine and a coolant branch flow path is branched at the front end of the engine coolant inlet to be connected to any one of the heat exchangers.

Vehicle thermal management system using two-port type integrated thermal management valve and cooling circuit control method of vehicle thermal management system

A vehicle thermal management system includes a plurality of coolant circulation/distribution systems that form an engine coolant flow, which circulates in an engine via mechanic/electronic water pumps, a heater core, High Temperature (HT)/Low Temperature (LT) radiators, an Exhaust Gas Recirculation (EGR) cooler, an oil warmer, an Auto Transmission Fluid (ATF) warmer, and an intercooler, in association with an Integrated Thermal Management Valve (ITM) and a Smart Single Valve (SSV). The thermal management system prevents turbo boiling at Ignition Key Off in association with the SSV and an Electric Water Pump (EWP) of the water-cooled intercooler while quickly implementing warm-up of the engine and the engine oil/ATF oil by the four-port layout of the ITM at the same time.

Vehicle thermal management system applying an integrated thermal management valve and a cooling circuit control method thereof

A vehicle thermal management system includes an Integrated Thermal Management Valve (ITM) for receiving engine coolant through a coolant inlet connected to an engine coolant outlet of an engine, and for distributing the engine coolant flowing out toward a radiator through a coolant outlet flow path connected to a heater core and a radiator. The thermal management system includes a water pump positioned at the front end of an engine coolant inlet of the engine, a coolant branch flow path branched at the front end of the engine coolant inlet to be connected with an Exhaust Gas Recirculation (EGR) cooler. and a Smart Single Valve (SSV) for adjusting an engine coolant flow in the EGR cooler flow path direction on the coolant branch flow path.

A cylinder block assembly may include a cylinder block, a cylinder body disposed in the cylinder block, with a plurality of cylinder bores formed in the cylinder body, a fluid jacket, which is formed between an inner circumferential surface of the cylinder block and an outer circumferential surface of the cylinder body, and through which coolant flows, and a block insert disposed in the water jacket and configured to guide a flow of coolant, wherein the cylinder block may include a second block coolant outlet, which is formed at a second side in a surface of an exhaust side of the cylinder block, and through which the coolant in the water jacket is discharged, and wherein the exhaust side may include a side at which combustion gas is exhausted out of the cylinder body.

Exhaust side block insert, cylinder block assembly including the same, and heat management system of engine including the same

The present invention provides a pharmaceutical formulation comprising clomipramine or its pharmaceutically acceptable salt (preferably, clomipramine hydrochloride) as the first active ingredient, and sildenafil or its pharmaceutically acceptable salt (preferably, sildenafil citrate) as the second active ingredient, wherein stability of clomipramine is improved, and a method for manufacturing this pharmaceutical formulation. In particular, the present invention provides a pharmaceutical formulation comprising the above two active ingredients and manufactured by using a wet granulation method, wherein stability of clomipramine is improved, and a method for manufacturing this pharmaceutical formulation.

Pharmaceutical composition containing clomipramine and preparation method therefor

The present invention relates to a pharmaceutical preparation for oral administration comprising, as an active ingredient, clomipramine or a pharmaceutically acceptable salt thereof; and a cation exchange resin and an anion polymer as a taste masking agent, wherein the pharmaceutical preparation can be orally administered even while comprising a pharmaceutically effective amount of clomipramine because the unique tastes of clomipramine, particularly, all of the bitter taste, spicy taste and burning taste are effectively masked, and thus the convenience of drug intake and portability is improved, and a method for manufacturing thereof.

Pharmaceutical preparation for masked taste oral administration, containing clomipramine

The present invention relates to a pharmaceutical preparation comprising entecavir as an active ingredient, wherein an antioxidizing agent is added to enhance stability of entecavir, and a method for preparing the same. According to the present invention, the invention has an effect that entecavir can be stably maintained in a pharmaceutical preparation containing a certain amount or more of moisture by adding the antioxidizing agent, thereby a pharmaceutical preparation can be provided as a formulation containing a certain amount or more of moisture, for example, an orally disintegrating film formulation.

Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor

The present invention provides a method for preparing a film comprising a high amount of a sildenafil free base uniformly dispersed therein and having a suitable thickness and size, as well as flexibility providing good handling stability and being not prone to breaking. The present invention also provides a sildenafil free base-containing film prepared from the method.

Sildenafil-free base-containing film preparation and method for producing same

The present invention relates to a method for preparing an itraconazole-containing solid dispersion. The itraconazole-containing solid dispersion according to the preparing method of the present invention has both improved solubility and rapid dissolution rate so that it has an excellent bioavailability. The itraconazole-containing solid dispersion of the present invention is also independent of pH variation of human stomach so that it can minimize the absorption variation of intra- and inter-individuals. In addition, the itraconazole-containing solid dispersion according to the preparing method of the present invention is stable for a long time. The present invention also provides an economical and environment-friendly method for manufacturing an itraconazole-containing composition because the method adds a lactic acid in a solution comprising itraconazole to decrease the amount of an organic solvent needed to dissolve itraconazole.

Manufacturing method of solid dispersion containing itraconazole

The present invention provides choline alfoscerate-containing pharmaceutical preparations which have improved storage-stability and are easily taken. The present invention also provides a method for manufacturing pharmaceutical preparations comprising choline alfoscerate, which is easy and simple and is performed by normal manufacturing equipments.

Pharmaceutical formulation containing choline alfoscerate

Growing community of inventors

Gyeonggi-do, South Korea

Bong-Sang Lee