Schering Corporation

Bong K Lee

Joseph A Marquez

Dinanath F Rane

Peter J Daniels

Gerald H Wagman

J Allan Waitz

The AR-5-3 Complex consisting of four macrolide antibiotics is elaborated by a mutant strain of Micromonospora polytrota. The antibiotics exhibit substantial activity against gram positive bacteria in vitro and in vivo.

Macrolide antibiotic complex

The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3'-N-methyl and 3'-N-methyl-4'-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.

Growing community of inventors

East Brunswick, NJ, United States of America

Bong K Lee