Korea Institute of Science and Technology

Bong Chul Chung

Jungyeob Ham

Taejung Kim

Pilju Choi

Seok Pil Lee

Sungdo Ha

Bong Geun Song

Man Ho Choi

Dong Hyun Kim

Young Tae Park

Deok Ha Woo

Hoon Ryu

Byung Hwa Jung

Hak Cheol Kwon

Hyun Ok Yang

Ju-Yeon Moon

Tae Jung Kim

Jin-Chul Kim

Buyng Su Hwang

Kyu Hyuk Jeong

Jungho Song

Hyun Hwa Son

Eun Gyong Yoo

Ki Sung Kang

Kyu Sun Kim

Su Nam Kim

Pil Ju Choi

Soon Hye Park

Provided are: a method of preparing a cannabis processed product having an increased CBN content in an efficient and economic manner, through cyclization of CBD and aromatization of THC by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBN content prepared by the method, a fraction thereof, and a single ingredient of CBN, in foods, drugs, and cosmetics.

Method of continuously producing cannabinol from cannabis plant and uses thereof

Provided are a method of preparing aprocessed product having an increased &#x394;9-THC content in an efficient and economic manner, through a cyclization reaction by microwave irradiation ofusing various extraction solvents, and use of the processed product having an increased &#x394;9-THC content prepared by the method, a fraction thereof, and a single ingredient of THC, in foods, drugs, and cosmetics.

Method of isolating tetrahydrocannabinol fromplant and use thereof

A large capacity natural material composition conversion apparatus using a microwave with a preset pressure function includes a chamber including a sealed reaction space accommodating a material, an radiator configured to heat the material by radiating a microwave into the reaction space, a pressure regulator configured to regulate a pressure of the reaction space by supplying a gas into the reaction space, and a controller configured to control the pressure regulator and the radiator, and preliminarily increase a pressure of the reaction space by controlling the pressure regulator before heating the material.

Large capacity natural material composition conversion apparatus using microwave with preset pressure function

Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

Method of continuously producing cannabidiol from cannabis plant and use thereof

Provided are a composition for stimulating insulin secretion from cells, the composition including aextract or an active ingredient thereof, and a method of stimulating insulin secretion from cells.

Composition for stimulating insulin secretion from cells and use thereof

The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure

Disclosed herein is a method for discriminating sitosterolemia by simultaneously measuring relative concentrations of phytosterol and cholesterol metabolism-related compounds in a blood spot on the paper. According to the present disclosure, sitosterolemia may be quickly discriminated with high accuracy by simple sample collecting using a trace amount of blood spot stained on a paper, and it may be used for newborn screening and preschool children, particularly patients with xanthoma.

Method for discriminatimg sitosterolemia using a dried blood spot

Provided is a method for selective extraction of steroid compounds using entrapped &#x3b2;-cyclodextrin polymers. Particularly, steroid hormones can be effectively selected from a biological sample by selectively extracting steroid compounds using entrapped &#x3b2;-cyclodextrin polymers, prepared by adding epichlorohydrin to &#x3b2;-cyclodextrin to prepare a polymer in a gel state, entrapping the polymer and pulverizing the products without using an additional device required in conventional solid-phase extraction.

Solid-phase extraction method of steroid hormones by entrapped &#x3b2;-cyclodextrin polymers

Provided are entrapped &#x3b2;-cyclodextrin polymers and a method of preparing the same. Particularly, entrapped &#x3b2;-cyclodextrin polymers are prepared by adding epichlorohydrin to &#x3b2;-cyclodextrin to prepare a polymer in a gel state, entrapping the polymer by entrapment of metal ions on the surface of the polymer and pulverizing the entrapped polymer to prepare powders. According to the entrapped &#x3b2;-cyclodextrin polymers, steroid hormones contained in a biological sample can be simply extracted without using an additional device required in conventional solid-phase extraction.

Entrapped &#x3b2;-cyclodextrin polymer and a method of preparing the same

Disclosed is a method of extracting all metabolites existing in a biological sample to detect a comprehensive difference between metabolites of a control group and a test group, thereby verifying significance thereof. More particularly, the invention comprises a first step of analyzing a fraction extracted with a solid phase extraction method, a fraction obtained by extracting the remnant fraction with a liquid-liquid extraction method and fractions extracted with the liquid-liquid extraction method at two pH different from each other after the hydrolysis, with a gas chromatography-mass spectrometry; a second step of converting the chromatogram result into numerical values capable of being statistically processed; and a third step of analyzing the numerical values with a principal component analysis (PCA) and a discriminant analysis (DA) to detect a difference between the control group and the test group. According to the invention, the difference between the two groups can be comprehensively detected with the areas of the peaks on the chromatogram, without a standard material or verified quantitative method. Therefore, it is possible to detect the metabolic change in the organism due to the disease or gene mutation, without an accurate quantitative analysis of the metabolites.

Growing community of inventors

Namyangju-si, South Korea

Bong Chul Chung