Korea Institute of Radiological & Medical Sciences

Inha University Research and Business Foundation

Bong Cho Kim

Jae-Seon Lee

Hyung Lee

Su Min Park

Je-Jung Lee

Na-Kyung Han

Seung Hee Jung

Mi-Na Hong

Provided is a composition for inducing tumor cell senescence and a method for inducing tumor cell senescence using the same. The composition can inhibit a PAPSS2 gene in a tumor cell to thereby induce senescence of the tumor cell, and if the composition is used concurrently with irradiation of the tumor cell, the composition can improve the sensitivity of the tumor cell to radiation.

Composition comprising inhibitor against PAPSS2 gene or protein encoded by gene for inducing senescence in tumor cells and method for inducing senescence in tumor cells using the same

Disclosed is an anticancer composition, comprising an inhibitor against WIG1 and/or YPEL5 or against a protein encoded by the gene. A composition for screening an anticancer agent comprising a nucleic acid having a sequence complementary to an mRNA of WIG1 and/or YPEL5, or an antibody to a protein encoded by the gene is also provided. Also, a method is provided for screening an anticancer agent, which comprises: (A) quantitatively analyzing expression of WIG1 and/or YPEL5 at an mRNA or protein level in a tumor cell which is not treated with a candidate for an anticancer agent; (B) quantitatively analyzing expression of the gene at an mRNA or protein level in a tumor cell after treatment of the candidate for an anticancer agent; and (C) selecting the candidate if the expression level of the gene is increased in step (B), compared to step (A).

Anticancer composition

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Gyeonggi-do, Japan

Bong Cho Kim