St IP Holding Ag

Bomi Framroze

Bret Berner

Michael Edward Grass

Mark Joseph Kastantin

Anthony Chris Garland

Barbara-Jean Anne Bormann-Kennedy

Casey Keith Jager

Corey Bloom

Jeffrey A Gelfand

Romain Bachelard

Jay Corey Bloom

This disclosure provides, among other things, rotomeric isomers of 4-alkyl-5-heteroaryl-3H-1,2-dithiole-3-thiones, complexes of such isomers in which an individual rotomeric form is obtained by stabilization, and compositions comprising an excess of an individual rotomer (a rotomeric excess) as a stabilized complex. The disclosure also relates to methods of making and using: such rotomers and complexes, including methods of treating a human or animal patient with such rotomers or complexes thereof, e.g., to prevent, treat or reduce the symptoms of various disorders such as mucositis, and/or provide protection against oxidative damage in various organs and tissues for a medical purpose.

Rotomeric isomers of 4-alkyl-5-heteroaryl-3H-1,2-dithiole-3-thiones

This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions.

Formulations of 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione, and methods of making and using same

This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions. Taste-modified compositions also are provided.

Formulations of 4-methyl-5-(pyrazin-2-yl)-3H-l,2-dithiole-3-thione, taste-modified formulations, and methods of making and using same

This disclosure provides, among other things, formulated oltipraz compositions comprising stabilized oltipraz crystals, for use in treating a patient who has a viral infection or is at risk of incurring a viral infection. Such viral infections can include a viral infection caused by a coronavirus such as one associated with MERS or SARS, e.g., SARS-CoV-2.

Methods of treating viral infections with formulated compositions comprising 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione

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Menlo Park, CA, United States of America

Bomi Framroze